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CENTERS OF RESEARCH TRANSLATION: RFA-AR-05-005
Purpose: The purpose of this request for applications (RFA) is to invite and support Centers of Research Translation (CORT) to foster research that is translational in nature, directed at elucidating the relevance of basic research to human disease in an area within the mission of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). Two major features of the CORT program include the overarching aim of disease-specific research translation and the inclusion of resources and an administrative structure to facilitate research translation.
Translational research is defined as applied and clinical scientific research that is directed toward testing the validity and limits of applicability of knowledge derived from basic science and engineering to the understanding of human diseases and health. It could be research involving living human subjects (ie, clinical), but it might also be nonclinical, involving the study of human genes, tissues, specimens, or cells. Thus, although it is directed toward generation of knowledge about humans, it could be nonclinical or clinical research. It could be knowledge useful to persons (individuals, families, populations) affected by or at risk of specific diseases.
Overall, the CORT should encompass a multidisciplinary approach to a disease-targeted theme. Individual projects must relate to the overall theme. For the purposes of the projects within a CORT, translation is not to be interpreted as requiring one project to depend on another. Rather, the outcomes of each project should inform the others. That is, the outcomes of a clinical research project would not be dependent on the outcome of a basic research project.
A CORT must be focused on one of the diseases in the NIAMS mission. The focus cannot be generic, for example, autoimmune diseases, musculoskeletal disorders, or skin diseases. The diseases within the NIAMS mission may be found at http://www.niams.nih.gov/rtac/funding/faq.htm.
CORT principal investigators …
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