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Purpose: This request for applications (RFA) solicits applications in the fields of genomics, proteomics, and metabolomics to identify novel biomarkers associated with alcohol exposure or alcohol-induced organ damage for their prognosis, diagnosis, screening, monitoring of treatments, and surveillance of recurrence. It can be anticipated that these global approaches, complemented with other traditional approaches, hold great promise for discovering many unique molecular fingerprints as sensitive and accurate biomarkers for alcohol exposure and alcohol-induced organ damage.

To achieve these objectives, several desirable features of biomarkers are necessary. At a fundamental level, the biomarkers must be accurate. For example, when used to measure alcohol exposure over time, they can distinguish harmful, problematic drinking from light to moderate, nonproblematic drinking or abstinence. When used in diagnosis of organ damage or its progression, the probability of their accuracy also has to be reasonably high. In addition, the assay should be reliable, yielding reproducible results. The biomarkers also have to be sensitive, using only a reasonable amount of samples. Furthermore, the samples or tissues used for biomarker …

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