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Purpose: Research supported and conducted by theNational Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), strives to understand, treat, and ultimately prevent the myriad infectious, immunologic, and allergic diseases that threaten millions of human lives. The NIAID Division of Microbiology and Infectious Diseases and the Division of Allergy, Immunology, and Transplantation support extramural research to control and prevent diseases caused by virtually all infectious agents. This includes basic biomedical research, such as studies of microbial physiology and antigenic structure; immunity; applied research, including the development of diagnostic tests; and clinical trials to evaluate experimental drugs and vaccines.

Through this request for applications (RFA), the NIAID invites research grant applications that will lead to the development of new vaccines, adjuvants, therapeutics, immunotherapeutics, or diagnostics focused on NIAID Category A, B, or C priority pathogens and toxins ( The objective of this program is to support applied research (ie, beyond basic research) and advanced product development; however, for the area of immunotherapeutics, basic research is also appropriate and will be supported. Research may include but is not limited to target identification (eg, compound screenings, epitope identification); the adaptation of platform technologies or products to biodefense applications; optimization of products; process development, early validation, and testing; preclinical evaluation; scale-up and production of quantities sufficient for preclinical regulatory requirements and clinical phase I testing or field trials. Applications that include collaborations between researchers …

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