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150 PREVENTION OF PERINATAL HIV TRANSMISSION: A TWO-YEAR RETROSPECTIVE STUDY AT THE UNIVERSITY OF SOUTH ALABAMA CHILDREN'S AND WOMEN'S HOSPITAL 2002-2003
  1. H. Kolbeck,
  2. T. Miller,
  3. M. Mancao
  1. University of South Alabama, Mobile, 1Helsinki University Hospital

Abstract

Objectives To describe the epidemiological and clinical characteristics of mothers with human immunodeficiency virus (HIV) infection who delivered at the University of South Alabama Children's and Women's Hospital (USACWH) from January 2002 through December 2003.

Methods Medical charts of all pregnant HIV-infected patients followed at the University of South Alabama Family Specialty Clinic (USAFSC) were reviewed; all patients delivered their infants at the USACWH during the study period. Patients' charts (mother and infant) were then reviewed for clinical, laboratory, and epidemiological data along with documentation of medication regimens and infant outcomes.

Results There were 16 mothers who delivered 15 infants in 2002, while there were 14 mothers who delivered 13 infants in 2003. The mothers' ages ranged from 15 to 39 years of age (median 22 years); 23 of 30 mothers (77%) were African American. Nineteen (63%) women had HIV RNA levels < 1,000 copies/mL and 14 (47%) women had absolute CD4 counts > 500 cell/μL. Twenty-six (87%) women received highly active antiretroviral therapy consisting of zidovudine, lamivudine, and/or nevirapine or nelfinavir. Sixteen (53%) women underwent cesarean delivery. All of the 28 infants born to HIV-infected women had negative HIV DNA PCR results at 4 to 6 months of age.

Conclusions There were 30 HIV-infected mothers who delivered 28 infants in 2002 through 2003. There were no infants born with perinatally acquired HIV infection in our study population.

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