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460 USE OF HIGHLY SENSITIVE C-REACTIVE PROTEIN IN THE SCREENING FOR HYPERINSULINEMIA IN OVERWEIGHT CHILDREN
  1. G. A. Mayman,
  2. W. N. Evans,
  3. R. J. Acherman,
  4. K. A. Cass,
  5. K. T. Kip,
  6. A. Rothman,
  7. C. F. Luna,
  8. L. Coviello,
  9. A. Gustafson,
  10. H. Restrepo
  1. Las Vegas, NV., 1University of Maryland

Abstract

Background C-reactive protein has been used as a putative biomarker of inflammation and potential predictor of adverse cardiovascular outcomes in obesity.

Objectives To assess the relationship between highly sensitive C-reactive protein (hs-CRP) with fasting insulin in non-diabetic obese children.

Methods The study included 125 overweight (BMI ≥ 95th percentile), non-diabetic children referred to our risk factor reduction program from February 2003 to May 2004. Hs-CRP, fasting glucose and fasting insulin levels were obtained. BMIs were assessed using 2000 CDC growth charts.

Results There were, 73 males (58.4 %), and 52 females (41.6 %). Mean age was 13.7 years (range: 2-18 years). For patients with hs-CRP ≥ 2 mg/L, mean fasting insulin level was significantly higher (26.3 μU/ml, SD: 26.5) than the mean fasting insulin level (16.9 μU/ml, SD: 13.3) of those with hs-CRP ≤ 2 mg/L, (P value ≤ 0.02).

Conclusions In this study of children whose BMI were greater than the 95th percentile; there was a significant difference in fasting mean insulin levels. An hs-CRP ≥ 2 mg/L could help to identify children with BMI's greater than the 95th percentile who have hyperinsulinemia and possibly insulin resistance.

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