Background C-reactive protein has been used as a putative biomarker of inflammation and potential predictor of adverse cardiovascular outcomes in obesity.
Objectives To assess the relationship between highly sensitive C-reactive protein (hs-CRP) with fasting insulin in non-diabetic obese children.
Methods The study included 125 overweight (BMI ≥ 95th percentile), non-diabetic children referred to our risk factor reduction program from February 2003 to May 2004. Hs-CRP, fasting glucose and fasting insulin levels were obtained. BMIs were assessed using 2000 CDC growth charts.
Results There were, 73 males (58.4 %), and 52 females (41.6 %). Mean age was 13.7 years (range: 2-18 years). For patients with hs-CRP ≥ 2 mg/L, mean fasting insulin level was significantly higher (26.3 μU/ml, SD: 26.5) than the mean fasting insulin level (16.9 μU/ml, SD: 13.3) of those with hs-CRP ≤ 2 mg/L, (P value ≤ 0.02).
Conclusions In this study of children whose BMI were greater than the 95th percentile; there was a significant difference in fasting mean insulin levels. An hs-CRP ≥ 2 mg/L could help to identify children with BMI's greater than the 95th percentile who have hyperinsulinemia and possibly insulin resistance.
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