Background Patients with DM2 are at an increased risk for cardiovascular disease. Novel risk factors for cardiovascular disease have emerged including plasminogen activator inhibitor-type 1, adiponectin and fibrinogen. The effect of meal composition and body habitus on these markers has not been well elucidated. The purpose of this study was to determine if meals of varying composition had different effects on these markers. Additionally the effect of body habitus on these changes was noted.
Methods 9 subjects with DM 2 were studied. Baseline HbA1C, BMI, Body Fat and Waist-Hip ratios were measured. Subjects were then admitted to the GCRC on two separate occasions. After an overnight fast, baseline labs were drawn. Subjects then consumed one of the two study meals, a standard fat (30gms) or a high fat (50gms) meal. Labs were repeated at 2 hour intervals for 6 hours. Subject returned one week later for the alternate test meal study.
Results Mean age was 57 yrs. (±5.6), Mean BMI 34.3 (±3.5), Mean waist/hip ratio 0.96 cm (±0.1), Mean body fat 43.6 % (±9.6) and mean HbA1C 7.04 % (±1.8). There was no significant correlation between the anthropometric measurements and any of the markers with either meal. (Table)
Conclusion We demonstrated the diurnal variation of PAI-1, with highest levels occurring in the morning. However, we were unable to demonstrate any significant differences in any of the parameters measured based on body habitus or meal composition. The data suggest a blunting of the normal diurnal decrease in PAI-1 following a high fat meal compared to a standard meal but statistical significance was not reached.