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Purpose: This program announcement is to solicit multicomponent applications on biologic mechanisms of aging in tissues and organs. Projects are encouraged that significantly advance basic biology research to understand how and why changes take place in tissues with age and how those changes relate to altered tissue and organ function. Projects that focus on molecular aspects, as well as cellular aspects of tissue aging, are encouraged. Projects are applicable under this announcement (a) that emphasize molecular and cellular changes that are common among tissues with aging; (b) that compare mechanisms of aging change in different tissues; and (c) that investigate the effects of age-related changes in one cell type, tissue, or organ that affect the function of another tissue or organ. Projects must have a clear relevance to aging to be considered under this program announcement.

Term/Amount: The mechanism of support will be the National Institutes of Health (NIH) research …

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